Saturday, August 31, 2019

Agreed Ways of Working Essay

Agreed ways of working, this is exactly how you will work. It is important to know what is expected of you in your role and in turn what to expect from others. In health and social care, there are agreed ways working you will have with an employer; also, with service users. Some examples of agreed ways of working in health and social care are: An agreed way of working with an employer would be to follow safety procedures relating to health and safety, for example, to follow the Food Hygiene Regulations 2005. This regulation concerns how food should be handled safely to avoid contamination and food poisoning. This is in order to protect the service user from potential harm; in addition, it is a legal requirement. An agreed way of working could be to protect the service user’s confidentiality. As long as a situation does not place the service user in danger or give cause for concern, then a care worker must keep information given to them confidential. It is the responsibility of the healthcare worker to handle information appropriately; this applies to all information whether it is an opinion given verbally, social information, or financial or medical records. If this agreement would be broken then trust would be lost between service user and carer; additionally, it is likely to cause disciplinary action. The refusal to accept any gifts or money from service users, their families or other carers, would be an agreed way of working. This would be to protect both employer and employee from any legal allegations concerning the gifts in the future; also, this protects the professionalism of both employer and employee and protects these boundaries. This would be an agreed way of working with both employer and service users. Another agreed way of working would be to conduct your work within your expected limits and abilities. In each job there are responsibilities and duties you are trained to perform, you agree to not exceed these limits; an example of this would be if a care worker administered medication to a service user without the appropriate training. Such an occurrence could cause serious or potentially fatal harm to the individual the care worker is supposed to protect, disciplinary action would be taken and possibly legal action additionally. An agreed way of working with a service user would be to treat the individual with dignity, compassion and respect.

Friday, August 30, 2019

Cabling and Factor Tools Essay

When choosing cabling for a network, there are several factors to consider: cost, Expansion capabilities, bandwidth, signal attenuation, and EMI (Electro- Magnetic Interference). Each type of cable has different specifications that affect these factors, and each organization has different needs. Considering Cable system factors is very important for building a network system that meets an organization’s needs. Now in the design of the installation of your cabling a poorly designed or installed network cabling set-up can reduce network performance. Today, data centers are growing and maturing, and cable management is becoming an important consideration. Proper cable management allows the fast identification of all system connections both at the physical layer and at the documentation level; good cable management also improves the maintenance of hardware equipment and the installation of new one; and finally, structured cabling management makes possible the effective cooling of the data center. You also have to consider fire and safety issues, for where you will be installing the cables. How they will be run throughout the building, will the cables be near other electrical cables and can it cause interference. Will the cableling be properly used under standards and local codes? And if not what would have to be done in order to makes sure it’s all up to code, and fire safety inspections. Some of the tools that will be needed for your installation will be Crimpers, Wire cutters/Stripper, Cable ties, Punch-down tools, voltage dectors, testing tools for when done. Also it would be smart to have a drill and bits/paddle bits, pliers, gloves, flashlight, and a tape measure. These are just a few things that would be useful to have. Prev Page Next Page Search

Thursday, August 29, 2019

Creative Tension Model Essay Example | Topics and Well Written Essays - 1000 words

Creative Tension Model - Essay Example The human mind is very unique in terms handling things. Every person has to manage a lot of things in his daily routine. Some things need more intention while the others hence the human mind prioritizes them accordingly. Every day there is a new challenge he has to face and he has to make the best of it. But at times our mind becomes so distorted that we are not able see a clear vision of things. This all effects our professional growth and family relationships adversely. Thus the creative tension model defines a set of rules and techniques that enable us correct those mistakes and help to make us a better person. In other words, this a structure that facilitates the creativity and change process in a person. The learning process of a person never ends. As a child we learn new things at every step of our age. In fact it grows on as the person keeps on experimenting new things. But there are certain ‘does and don’ts’ which are instilled into our lives from the very beginning. Similarly, such implications create fear in us and a kind of unworthiness settles in our minds for the things we can have and the things which are totally out of question for us. Peter Senge in his book â€Å"The Fifth Discipline† states as it is believed that there are two contradictory beliefs that can limit our ability to create what we actually want. Out of them the most common one is believing that we are powerless and our failure in being what we actually want to be. The other one center’s around our unworthiness that we do not deserve to attain what we truly wish for. (Senge, 2006) Creative tension can be defined as a tension between your current reality and your vision or goal. Robert Fritz has explained creative tension using the example of a rubber band stretched across your vision and your current reality. As you move towards your vision, the rubber helps you pull in your desired direction. This tension symbolizes motivation, the more

Wednesday, August 28, 2019

Analysis of Civil Rights Movement Freedom Riders Research Paper

Analysis of Civil Rights Movement Freedom Riders - Research Paper Example On the one hand, some would say that they failed due to the reality that many of them were beaten and arrested. On the other hand, their message resonated with many across not only the South, but the nation as a whole. That message was designed to end the prejudice and segregation that still existed a century after the end of the Civil War. While policy changes may not have been initiated as a direct result of the Freedom Riders, the reality is that these activists highlight a rift within American society that would have to be dealt with. As a result, the Freedom Riders did end up having an impact of the Civil Rights movement by strengthening the voice of the African American person, bringing attention to the pervasive problem of segregation, and moving the government towards action in the end. Frustrated from a lack of transportation services, and the reality that those offered to African Americans at the time were of a substantially substandard quality in comparison to whites, many in the African American community felt that they needed to be more proactive in making their voices heard and begin the process of desegregating the South once and for all. The rides are believe to have actually begun in force on a Mother’s Day in 1961. As history has revealed, one of the most segregated areas of the country was the rural South, and Alabama was prime territory to enforce segregational laws and policies (Manby, 2012). The African Americans in this area were not heard and they had no voice in local or state politics. As a result, some brave white and many blacks took it upon themselves to begin to be heard. The freedom riders themselves actually integrated certain Greyhound bus routes, mixing black and white passengers, at great risk of personal injury. In many locations, such as the first report event in rural Alabama in 1961, a

Tuesday, August 27, 2019

Ethics Essay Example | Topics and Well Written Essays - 1500 words

Ethics - Essay Example Ethics refers to the moral principles and set of laws of conduct that are universally acceptable to the majority of people (Arnhart, 1998). Apparently, human beings get accredited for having an innate ethical sense, which urges them into making predictable choices (MacKinnon, 2010). Whereas the majority of people consider their actions as getting guidance from logic and the reason, it appears that, in most cases, reason acts only as a device for justifying these options. Language gives people the opportunity for constructing sophisticated rationales that tend to support decisions that happen to be genetically driven (MacKinnon, 2010). Therefore, ethics education entails the recognition of the real power of a person’s innate ethical sense, along with the manner in which it affects his or her behavior. In this manner, a person is capable of freely reasoning and becoming an element that truly guide his or her actions hence devoid of the wisdom resulting from comprehending a perso n’s innate ethical self, reason continues to be a powerful propaganda piling for unchallenged essential human, ethical obligations (MacKinnon, 2010). The ethical actions tend to be valuable despite the consequences of those actions. Apparently, there is a possibility that the practice of ethics came to pass by natural consequences, as well as the actions, eventually this resulted in people making a decision of fitting the actions to the box by establishing a word for defining it that is ethics (Arnhart, 1998). When a person works industriously and is effectual, as well as professional in his or her duties, this means that he or she is engaging in vigorous work ethics. In most cases, this leads to the person getting a promotion and earning respect from fellow workmates who are incapable of attaining these standards (Arnhart, 1998). In this case, the reaction, together with the outcomes of decent work ethics or even upstanding, moral principles, along with the personal rules of conduct have resulted in this person excelling above the others. Consequently, when other people see the results of this person’s actions, they desire to emulate him, thereby beginning to behave in similar positive work ethic behaviors (Arnhart, 1998). On the other hand, other people with substandard ethical behaviors attempt to get similar results through cheating, lying, as well as falsifying information; this results in them being not as successful as the ethical person since their actions eventually return to bite them at a later stage. Consequently, people observe the outcomes leading to the majority of people choosing to be ethical since the ethical behaviors tend to be extremely successful, while, at the same time produces enhanced results at the end(Arnhart, 1998). This happens to be an ideal example of ethics as a learned behavior. Human beings have the freedom of determining what they perceive as being ethical behaviour considering that these decisions tend to have an effect on the human responsibility (MacKinnon, 2010). Apparently, the issue of ethics goes way back in time with highly ethical behaviors succeeding the unethical behaviors. As a matter of fact, in most cases, the truth always prevailed then as it does now, considering that ethical behavior gets rooted on the truth while unethical behaviors are not (Nelson, 2011). The majority of theorists contend on the notion of moral and evil; a person believing in the existence of inherent moral or

Monday, August 26, 2019

Examine the ways in which attempts are being made to address the Essay

Examine the ways in which attempts are being made to address the problem of cyber bullying in the criminal justice system of England and Wales - Essay Example There are various criminological theories that have been proposed to help in understanding the mind of the criminal. Some of these theories suggest that the society is to blame for creating criminals while other theories base their arguments on the view that criminals are born and not made. With Face book and Twitter being the most popular social networking sites in the UK, cybercrime is on the increase. In England and Wales, cyber bulling is considered an offence under law. The choice theory helps in explaining the way a criminal’s mind operates in leading him to commit a crime. The bully’s reasoning is thereafter transferred on to the victim who believes whatever the bully says. The insufficient regulation of social networking sites has led to more cases of cybercrime in the UK. Children have committed suicide following the cyber bully’s opinion about the child. This essay seeks to examine how the rational choice theory can help the justice system in England an d Wales against cybercrime. Every victim of crime wonders why people commit crime. Studying criminology helps an individual understand why people commit crime. This helps in understanding how the criminal thinks and come up with ways in how to assimilate the criminal while controlling crime. There are several theories of why people commit crime. Others propose that the individual decides to commit crime consciously while some believe that the community is responsible for crimes committed. With all the varied theories of crime available, an agreement are made that, fairness should be available in any society. In this essay, the rational choice theory will guide in understanding a criminal’s mind and ways of combating crime in England and Wales using this theory. The rational choice theory proposes that an individual chooses to commit crime once the pain and punishment

Sunday, August 25, 2019

Globalisation Essay Example | Topics and Well Written Essays - 1000 words - 5

Globalisation - Essay Example The terms became prominent during the 1990s with the end of the Soviet Union Cold war. This is a major change which is steady and is one which includes complete integration of various countries. Globalisation refers to the interaction among different countries in order to work together to develop the global economy. Here there is generally an integration of economies and societies across the world. Globalisation is an opportunity that opens us many different areas for more interaction among people across the world (Kose, 2003). In terms of social as well as business activities, globalisation opens up opportunities to allow better communication and interaction without the issue of locations or borders. Stephen Gill explains globalisation to be a method which helps in reducing the costs by means of transaction and Trans – border movements of goods as well as capital and other factors of production. Guy Brianbant has however explained globalisation to be a process which includes a number of different factors like the improvement of communication, financial markets, and also internationalisation of the companies and growth of the multinational companies along with better mobility of people and factors like capital, data, goods and ideas. He has however also taken into account the negative aspects of globalisation i.e. higher mobility of infections, diseases and pollution (Mooney & Evans, 2007). This provides an overall and well rounded explanation of the process of globalisation and takes into account all perspectives of globalisation. Globalisation as has been discussed has impacted almost every country in the world, either positively or negatively. Here in the case of UAE, the country has been of interest and the collaboration between the country and other international locations has played a major role in the development of the country (Patapan, 2007). The Government of

Saturday, August 24, 2019

Leading the Way - A Marketing Plan for Sustainable Competitive Essay

Leading the Way - A Marketing Plan for Sustainable Competitive Advantage - Essay Example Apple may have to invest a great deal of financial and human capital effort into performing market research to gain new market interest, something the firm is not experienced with as, historically, Apple has chosen to focus on developing existing markets through product development strategies. Marketing Strategy and Analysis for Apple, Inc. 1.0 Introduction Apple, Inc. has long been considered a pioneering company; an innovative organisation that develops unique products with features and benefits unavailable by competition that gives the business a positive market position. Marketing has been one of the fundamental success factors for Apple, especially in relation to launch of the iPod, iPhone and iPad, methods of differentiating the business from other competition. Marketing is defined as being all-inclusive of all activities related to commercial exchanges that involve advertising, branding, distribution, establishment of pricing structures, and responding to consumer behaviour pa tterns (McCall 2003). Apple successfully utilises marketing in order to build relationships with consumers that lead to brand loyalty, attachments that have consumers favouring Apple branded products over other competitive products offered by such competitors as Samsung and Blackberry. Apple focuses on building a brand, a holistic representation of the business that is reflective of quality and internal corporate values. Branding is a strategy that creates the ability to build connectivity between internal market-centric assets and important target markets that allow a business to nurture its resources effectively (Abimbola 2001). Apple maintains a brand strategy that reflects emotional appeals, building a brand personality that emphasises such consumer-centric concepts as â€Å"inspiring passion and hope, power-to-the-people through facilitating technology, imagination and liberty regained† (Robinson 2012, p.2). This is how loyal markets view Apple as a leader in the technol ogy industry. 2.0 Responses to competitor activities Apple uses marketing as a tool to create perceptions in desired target markets that Apple products and services as superior to competitor brands. Apple is adept in creating pioneering products that have relatively long product life cycles as competitors are not able to quickly replicate the features and benefits of Apple branded products. Apple, in the early 2000s, was able to gain favourable market attention and brand preference with diverse markets by being the first-to-market. According to marketing theory, the publicity associated with pre-launch activities set up the foundation for brand loyalty. When a first-mover achieves positive gains with an innovative product, they actually define the product category and are seen as a model by which consumers evaluate late movers (Agarwal and Gort 2001; Liberman and Montgomery 1988). Apple is not generally taken to creating marketing strategies as a response to competitive efforts, but to build proactive methodologies of promotion that enhance its public brand reputation through media coverage. The former CEO, Steve Jobs, used to serve as a relevant and trusted celebrity endorser that engaged many diverse consumer

Friday, August 23, 2019

Analysis of IT Services in Business Essay Example | Topics and Well Written Essays - 3000 words

Analysis of IT Services in Business - Essay Example By 2003, the company was earning good revenues with offices opened in US, UK, Japan, Germany, Australia, and Singapore, along with manufacturing capacity at Penang and Malaysia. Terra was still in quest of expanding its business further however, it did not have sufficient funds after all heavy investments (CMIS, 2010). Therefore, for the first time, it decided to invite outside investors to help terra in expanding its product lines. These investors included the owner of â€Å"country’s largest sheep farm, an award-winning film director, an actor known for his temper and fondness for rugby and inventor of bungee jumping† (Blanchard & Bowles, 1998). Though these investors did not have much knowledge about corporate world, they wanted the Frost brothers to hire a professional management team (Blanchard & Bowles, 1998). Despite huge opposition for this decision, Frost brother ultimately appointed Stephanie Clark as vice president of IT and Operations.Her colleagues called t his woman as â€Å"force of nature† as she possessed diverse abilities from looking into the details of any operational problem to encouraging the employees keeping in mind the broader goals of the company (CMIS, 2010). She majorly focused on planning and execution, which did not influence firm’s engineering culture. They assumed that they could not perfect the products if there is a fixed schedule or budget for them. These clashes were at height in 2005 when the company was trying to make a filmless X-ray system.... By 2003, the company was earning good revenues with offices opened in US, UK, Japan, Germany, Australia, and Singapore, along with manufacturing capacity at Penang and Malaysia. Terra was still in quest of expanding its business further however, it did not have sufficient funds after all heavy investments (CMIS, 2010). Therefore, for the first time, it decided to invite outside investors to help terra in expanding its product lines. These investors included the owner of â€Å"country’s largest sheep farm, an award-winning film director, an actor known for his temper and fondness for rugby and inventor of bungee jumping† (Blanchard & Bowles, 1998). Though these investors did not have much knowledge about corporate world, they wanted the Frost brothers to hire a professional management team (Blanchard & Bowles, 1998). Despite huge opposition for this decision, Frost brother ultimately appointed Stephanie Clark as vice president of IT and Operations. Her colleagues called this woman as â€Å"force of nature† as she possessed diverse abilities from looking into the details of any operational problem to encouraging the employees keeping in mind the broader goals of the company (CMIS, 2010). She majorly focused on planning and execution, which did not influence firm’s engineering culture. They assumed that they could not perfect the products if there is a fixed schedule or budget for them. These clashes were at height in 2005 when the company was trying to make a filmless X-ray system for dental and veterinary uses. Clark was getting this made because she could see a hidden opportunity in this segment. She knew that film-based imaging technique was relatively low-priced but their cost

Distinct varieties of masculinity Essay Example | Topics and Well Written Essays - 1250 words

Distinct varieties of masculinity - Essay Example ne, by concurring or differing with different scholars; the conclusion, entailing a summery outline of the main points discussed and a stand on the things discussed and how masculinity manifest. In gender studies, feminist theories concern the discrimination of women by men because of womanhood feminists opine that men suit themselves by controlling sex; women get denied personal choice and exploited on labor issues. The feminists believe that the discrimination curtails women rights and seek to see the situation changed. (Piper 2009) Masculinity refers to masculine which denote something related to a male who include men and boys. (Piper 2011) defines masculinity as an expression to serve and not to be served expressing a sacrifice for the woman, which requires giving direction and having a final say. While looking at the distinct values of masculinity arises from the comparison of feminist and masculinity where feminist seek for equality between men and women, but some things constitute for womanhood and others manhood. The essay below discusses the comparison of the two in regard to distinct variety of masculinity. Distinct varieties of masculinity To begin with thoughts and experiences of men, they help in understanding gender in terms of the masculine variables, as opposed to feminist. (Rotundo, p. 106) argues that women beauty lured men from their known pleasure and secure culture to following women. Therefore, opining that gender gets socially construed with masculine thoughts and behaviors arising from social and cultural processes. The scholar opines that the new complex culture, give rise to the conception of self made manhood. (Rotundo, p. 80 ) Explains the boy’s culture, which prepared boys, for rough and competitive world of politics and business, also the youth culture characterized by debating clubs, where they learned new skills and how to compete in socially acceptable ways. Similarly, (Rotundo, p 86) expresses the idea of masculinity by

Thursday, August 22, 2019

The Magna Carta and the Constitution Essay Example for Free

The Magna Carta and the Constitution Essay Magna Cartas original version which states that the king should not ignore or violate the traditions, customs or laws and could not take any arbitrary actions against his subjects. l Magna Carta provides for rule of law, ensures fairness tOf3 0T laws, contalns commitment to Oue process 0T law ana gives respect Tor economlc rights. While these rights were the privileges given to barons in England by way of declarations in Magna Carta, the founders of the U. S. drew inspiration from Magna Carta and made these rights applicable to all the citizens of America and became part of the Bill of Rights. Magna Carta is therefore a source for the U. S. Constitution. The Bill of Rights 1791; which representing 10 amendments as part of the 1st amendment to the U. S. Constitutions. Clause 39 of Magna Carta provides that no freeman shall be punished except by lawful Judgment by his peers or by the laws of the land. This was to prevent the King to deliver sentences without the authority of law. The U. S. Constitution provides for rule of law by which no person is above the law. In this context both, Magna Carta and the U. S. Constitution are similar. Whereas the Magna Carta was issued by the Monarch, the U. S. Constitution was given by Americans unto themselves. The 14th Amendment to the U. S. Constitution includes the stipulation of due process, this provides for fair trial before depriving any person of his life, liberty or property. The trial is what is meant by due process. Again it must be a fair trial as part of the due process. In The Magna Carta, the due process of law is known by law of the land and legal Judgment of peers. In order to constitute due process, there should be a right to fair and public trial, right to be present at the trial, presence of an impartial Jury, right to be heard as part of ones own defense. Besides, the laws must be in written form, taxes must be for only public purpose, and property can be taken only for public purpose with due compensation. In this way The Magna Carta pales in comparison due to not being as descriptive as the U. S. Constitution for the meaning of due process. Both Magna Carta and the U. S. Constitution require that laws shall be fair and discriminatory. Thus, Magna Carta and the U. S. Constitution share many things in common. Magna Carta of 121 5 was a bold initiative of the then King, without which the U. S. Constitution would have taken still longer time to be what it is today.

Wednesday, August 21, 2019

The Role of Technology In HSBC

The Role of Technology In HSBC HSBC is known as one of the largest financial and banking services industries in the global background. Background HSBC know largest industries in the global financial and banking services as a. The company is headquartered in London and has an international networks which composes of over 10, 000 offices in more than 82 states and territories within Asia-Pacific Region, Europe, United States of America, Africa and Middle East. HSBC Holdings Plc are regarded to have around 200,000 shareholders in over 100 nations as noted in listings in countries like New York, Bermuda, Paris and Hong Kong. HSBC Holdings Plc, the company is located in east London and an international network which composes the mid 10, 000 offices and more than 82 African states and regions within Asia Pacific region, Europe, United States of America are , counting the 100 countries around 200,000 shareholders in countries such as New York as mentioned in the listing, Bermuda, Paris and Hong Kong. Because of the globa l network connects by the implementation of advances technology like the internet and information communication technology, the company has been able to provide an intensive range and reach of financial services which includes commercial banking, investment banking and market personal financial services, and other banking and financial products and services. The business philosophy of HSBC gives important to values and principles in all aspects of everyday living. Because of the global network communications and information technology like the Internet by following links to technology development, corporate and other, has been to provide services worth an extensive range financial and personal financial services to reach including commercial banking, investment banking and markets, banks and financial products and services. HSBCs business philosophy in all aspects of everyday life and gives the principles of values is necessary. INTRODUCTION OF HSBC: HSBC Introduction: HSBC is one of the largest banking groups in the world today. HSBC todays worlds biggest banking group is one. It has been ranked fifth largest company in Forbes Global 2000 and the third largest banking company as well. Forbes Global, the company in 2000 was ranked fifth largest and third largest banking company as. HSBC head office is located in the HSBC Tower in Londons Canary Wharf. HSBCs head office tower in Canary wharf London, HSBC is located. The HSBC group is named after its founding member, the Hongkong and Shanghai Banking Corporation, a bank established by, a Scot, to finance British trade in the Far East in 1865. Member HSBC Group is named after its founder, Hong Kong and Shanghai Banking Corporation, a bank founded by a Scot, in the 1865 Far East Finance business in the UK. HSBC has about 10,000 offices worldwide with 232,000 employees in 76 countries and territories. HSBC regions and 76 countries with 232,000 employees worldwide with about 10,000 offices. With its 110 million customers worldwide, a total of 16.5 million are e-based. 110 million from its worldwide customers, a total of 16.5 million is based on E. HSBC has really proven that it is The worlds local bank. HSBC has proved that it really the worlds local bank. The bank is the second largest corporation in the world in terms of assets. Bank assets in the world of words is the second largest corporation. It reports its results in US Dollars since 80% of its earnings come from outside the UK. This revenue comes from outside the UK in the U.S. results reported 80% of the dollar. Nearly 22% of its earnings comes from operations in Hong Kong. Before moving the headquarters to London in1991, it was headquartered in Hong Kong. Approximately 22% of the revenue operations in London, Hong Kong Kong headquarters before arrival. in1991, was located in Hong. Has the organization restructured recently? Recently reorganized company? If yes, why? 1) If yes, why? If no, why not? 2) If not, why not? What have been the consequences? 3) What results have been? Would most complex, large organizations have several functional grouping approaches? Does this matter? 4) is the most complex, large organizations view is planning several work groups? What? HSBC is a public limited company incorporated in England and Wales. HSBC Wales, a public limited company incorporated in England. Headquartered in London, the HSBC group operates in five regions: Europe; Hong Kong; the rest of Asia Pacific; including the Middle East and Africa; North America; and South America. Located in London, HSBC in five working groups in the region: Europe, Hong Kong, the rest of Asia Pacific, Africa and the Middle East including, North America and South America. The entities in which form the HSBC Group provide a comprehensive range of financial services to personal, commercial, corporate, institutional and investment, and private banking client. To more easily promote the Group as a whole, HSBC launched a campaign to differentiate its brand from those of its competitors by describing the unique characteristics which distinguish HSBC, summarized by the words The worlds local bank. A wide range of financial services for private corporation, as, commercial group s and investment institutions, and private banking clients. Promoting more easily provided in the institutions which form HSBC Group, HSBC brand difference between the start of the campaign for HSBC prominent features unique compared to those defined by, Proceedings of the words from The worlds local bank. Through the years since 2004, HSBC has gone through a lot of changes. Years since 2004, HSBC has gone a lot of changes. In 2004, the Bank of Bermuda joined the Group and minority stakes were acquired in Indias UTI Bank and Chinas Bank of Communications Ltd. In the UK, HSBC bought the retail financial services arm of the Marks and Spencer Group. In 2004, Bank of Bermuda joined the group and a minority stake in UTI Bank was acquired by India and China Bank of Communications UK Limited, HSBC group brought signs and Spencer retail financial services arm. The HSBC brand was adopted by its Mexican subsidiary, GF Bital, early in the year and in September the majority of the banks North American businesses, including Household International, were united under the name HSBC North America. HSBC North American brand business September of the majority of banks was adopted by Mexico, equipment and years GF, Bital skin, including Household International was the United Nations under the name HSBC N orth America. ROLE OF TECHNOLOGY HSBC: HSBC role of technology: Modern information technology (IT) is understood to be the result of a meeting between modern digital computing and communication technologies. Modern information technology (IT) and computing the modern digital communication technologies between the outcome of this meeting is to be understood. The significance of IT is as the core of an Information System which consists of a series of interactions between people, data, hardware and software, organizations and their social environment. The importance of this , is a foundation of information system which the social environment and their organization consisting of a series of conversations between people, data, hardware and software. Information and its connected technologies are now so vital to business success that information is regularly regarded as an independent issue of invention on a same level with capital, land and labor. Information and technology vital to business success now that information with the investors and workers, the level of invention on a routine matter as an independent count. In the twenty-first century every business manager must understand the role which information technology plays, not only in their organization but also in the wider society, within which their organization must compete. Competition, the twenty first century will be all business on their organization and understand the manager role should not information technology plays in society is widespread, organized them. A full understanding of information technology is impossible without considering its communication with the social world in which it has developed. A complete understanding of information technology has developed the world it is impossible without considering the social communication with him. Computer professionals who are ignorant of the social, political, and economic political aspect of their work are fated to be the put up of decision-makers who are. Computer professionals who work with them are ignorant, political, economic and political factor is social tolerance are lucky by which decision makers. In the real world a frequent cause of the failure of IT projects is an overlook of the human (including managerial and organizational) factors at work. No business or computing professional can, therefore, ignore the softer elements in Information Systems, which paradoxically, often prove the hardest to get right! Failure in the real world because of her projects is a continuous work in an organization), including the management of human factors and pass, any business or computing system, therefore, ignored information about business, can elements in Medium which, unlike, most of the right to prove the most difficult to achieve! THE COMPUTING ENVIRONMENT: computing environment: Linking together definitions of information and technology from the Shorter Oxford English Dictionary, information technology means the systematic study of the industrial arts relating to the communication of instructive knowledge. Adding information with praise and English Dictionary Oxford technology from small, information knowledge of technology communication education means related art industrial training conducted. This definition includes studying printing, or, for that matter, smoke signals. Included in this definition, studied printing or, for that matter, smoke signals. However the general usage today, is more like the definition employed by (1988,) the application of computers and telecommunications to the collection, processing, storage, and dissemination of voice, graphics, text, and numerical information. However, general use today, storage is much appreciated by this work (1988, applied for) of telecommunications and computer storage, processing, and dissemination of s ound,, text, graphics, and numerical information . One famous development in recent years has been the convergence of communications and computer technology, with both becoming intensive users of data embodied in binary digital form and processed by microprocessors on silicon chips. Popular in recent years on developing a silicon processed by microprocessors and chips is in binary form with digital technology, computer and communications convergence was embodied both figures to be intense users. Therefore IT is normally used in the broad modern sense to encompass both computing and telecommunications technologies. In some books, IT is used more narrowly to refer principally to computing and ICTs to refer to information and communication technologies more generally. So this is the sense commonly used in modern comprehensive coverage of both computing and telecommunications technologies. Some books, usually it is used more narrowly refer technology and communications and for basic computing and information refer to the ICTs. If we consider the industrial and commercial implications of the employment of the new information technologies then we must take on board that the computer is a general purpose machine which mechanizes human brain-powered operations just as the Industrial Revolution mechanized human and animal muscle-powered operations . If we then consider the implications of new information technology jobs industrial trade and we must take on board power operation is a general purpose computer machine machine revolution muscular man and animals mechanizes the human brain only industrial strength operation. The impact of such a broadly applicable technology is inevitably widespread and far-reaching. Broadly applicable technology and its effect on reaching such a broad and excesses, yet. Computers have become a pervasive technology applied in all sectors of life, including industry, commerce, government, education and leisure activities. Computers have become leisure activities, and education, trad e, expanded a government, technology apply to all areas of life, including industry. For businesses, information technology is only a means to an end which is the use of knowledge to make and implement commercial decisions. For business, information technology, only a means to an end which is used in the decision to apply knowledge and trade. Efficient organizations require established systems to enable them to make the best possible decisions in the situations they are likely to meet. Organizations need to establish efficient and meet the systems potential to make the best decision possible situations are worthy of them. Thus an organizational information system should collect data, analyze, and present this as useful information that can be retrieved as the basis of expert knowledge at the point of decision. Thus, an organization information system should sum data analysis, and present it as a benefit that information can then decide based on expert knowledge. Once decisions are made they must be passed on to those who implement them, carried out, and the success or failure of the operation monitored. Decisions are carried by them for what they passed on, and success or failure of the surveillance operation outside a bar. Increasingly decisions can be automatically implemented using the technology, thus enabling organizational objectives to be achieved with maximum efficiency. Increase can be determined using techniques applied automatically, thus enabling organizational objectives with maximum efficiency can be achieved. DAY TO DAY BUSINESS: Business Day Day: Achieving Competitive Advantage to gain competitive Four alternative strategies for achieving competitive advantage: doing it better, marketing it better, doing it differently and making yourself indispensable. Better marketing, better four alternative strategies to achieve competitive advantage for doing, (it, are different and need to make yourself. Doing it better. First, the customer may be brought to think that your firm is doing the same thing better in some way than others either the product or service is better than others, or it is as good as others and produced more cheaply, or perhaps it is delivered more conveniently to the consumer. To do it better than before. , Customers may take more than cheap products that your firm is better at talking about what others some way either service or product is better than others or that, is as good as others, Or maybe it was more for the convenience of users is. The obvious way to do this is to deliver a better, cheaper or more convenient product. A higher specification product (eg a more durable one) can be produced to higher quality standards (eg fewer defective goods sold), with better production methods or cheaper sources of supply than competitors can find. Clear that the way to deliver more products feature a better, or cheaper.) A durable high specification products (eg goods at a cheap multiple, for example) can be produced (sold cheaper or higher quality standards, better production methods with more than competing sources of supply can find. The same product or service can be delivered to the door of consumers on demand rather than forcing them to wait for or collect the product. the product or products and services together to force them to wait to but the door may be asked to deliver users. Thus more sales and / or greater profits can be achieved. thus more sales and / or can benefit from. Marketing it better. On a suspicious note it must be sharp out that an other is to prove to your customers that they are getting some or all of these advantages without necessarily delivering them. Note that better marketing should be a quick one out of another dilemma that required them to prove the benefits without doing it all, or that your customer. A large sales or marketing effort may, to a degree, be a alternate for lead in the actual product. In the long term, though, it is probable that consumers in most markets cannot be fooled indefinitely. A big, try a degree in marketing or sales can, in fact led to product an alternative indefinitely long. In the term, though, is a fools also possible that users can not market the most. But, in any case, it must be said that many excellent products have failed to sell because the consumers did not know about them. But, no matter, they should be said about that many users did not know that the best selling product due to failed. In many cases effective brand management of a good product or service can effectively create a demand for, say, Coca-Cola which is different from the demand for soft drinks. In many cases very effective product or service brand management for a soft drink can effectively create a demand for, say, Coca application is different from the cola. Producers can create a sort of monopoly by establishing a difference between their version of the product and other versions. Manufacturers of other products and prescription versions of the difference between them established by a kind of monopoly can be. Doing it differently. An other strategy to achieve competitive advantage is to innovate, as we touched upon under the heading of intellectual property. Different from doing so. Another strategy to achieve competitive advantage to innovate, as we are touched upon the intellectual property under. If your product really is different in kind to the competition then a substantial competitive advantage may well result. If your product is different and in fact, how much competition competitive advantage may well result. Your new product will certainly be protected from competition by a time-lag before your competitors can invest in the necessary plant or skilled personnel to produce the new product. Will your new product to compete with a lag time necessary to secure required before products can your competitors or efficient investment in new staff ready to plant. You will probably generate a marketing advantage through being first in the field including free publicity in the media and per haps identification of the product with your brand name. You may benefit by creating a marketing area is being the first including the independent media and media in the name of their products with brand identity might. Additional protection may be available under patent law, design right and copyright. Additional security can be copyrighted and available right under design patent law. Making yourself indispensable. A more delicate strategy is to attempt to engineer a situation in which your service or product is taken for granted. Must make your own. A more delicate strategy is taken for granted is to engineer products or service status for what you. The customer does not stop to make comparisons but automatically re-orders your product or service. Customer service or product comparisons do not stop automatically re-order your. An example might be book or record clubs automatically delivering the current choice of the month. For example, maybe a month book club or record supply current selection automatically. At one stage IBM were happy to accept the myth that no one ever got fired for buying IBM. Corporate clients employees were trained in IBM technology, their managers were offered upgrades on existing equipment on favourable terms, and the effort required to move out of an assumption that the next generation of equipment would also come from the Big Blue was c onsiderable. An IBM platform for buying IBM was happy to accept the analogy is true that nobody ever got fired needs. Corporate clients employees were trained to IBM technology, according to upgrade their existing equipment manager had been offered terms, and was enough Blue moved to think that a big next generation equipment is coming too. SOCIAL ASPECT: social aspects: HSBC is being affected by the situation of the society in which they are operating. Along with this, HSBC tries harder to make sure that each society is given equal chances to take advantage of the resources given by the organisation. Work that is being affected social situation, with the HSBC HSBC tries hard to ensure that the organization provide to take advantage of every resource for society is given equal chances. The company hold fast to having good reputation and relations in the society that they belong. They hold fast to the companys good reputation and relationship that society. As you approach retirement you have hopefully created a retirement plan sufficient to maintain your lifestyle. Alternatively, you might look to start easing your way into retirement by working part time. As you near retirement, your life you hope to maintain adequate to create a retirement plan. Alternatively, you from working part time retirement easy way to start your can see. Your pension will pr obably be your main priority. Its important to think about whether it will be enough to provide income for a comfortable retirement at your desired retirement age. Your pension retirement age is perhaps his main desire. You prefer for a comfortable retirement, provided that income will be important enough to think about it. TECHNOLOGICAL ASPECT: Technical aspects: The appearance of information technology and internet affects how HSBC has been operating in the past years. Information Technology appearance and how the Internet affects HSBC has been operating in the past year. The company adopts different IT / IS systems and used internet to reach their customer all over the world and to know the latest trends in the global business. Different control company T / systems and Internet access in the world to reach their customers and businesses worldwide know the latest trends. Aside from these, the company also uses facilities which helps them improved their productions and operations.

Tuesday, August 20, 2019

Secretors And Non Secretors In Human Population Biology Essay

Secretors And Non Secretors In Human Population Biology Essay Human population can be categorized into secretors and non-secretors. They are categorized on the basis of presence or absence of the blood group antigens (A, B and H) in the body fluids and secretions, such as saliva, sweat, tears, semen, serum, mucus present in the digestive tract or respiratory cavities etc. Secretors are individuals that secrete blood group antigens in their body fluids while non-secretors are the individuals that do not secrete them in their body fluids and secretions. It is a known fact that ABO blood type is controlled by blood type coding genes present on the chromosome 9q34 but the secretor status of an individual is decided by interaction of a separate gene (called secreting gene) with these blood type genes. The presence of the secreting gene in a persons genome makes him a secretor and absence makes him a non secretor. The gene is designated as (Se) for Secretors and (se) for Non-secretors and it is entirely independent of the blood type A, B, AB or O. The individuals secreting antigens in the body fluid are designated as ABH secretors in blood banks. Individuals having O blood group secrete antigen H, A blood group secrete A and H antigens, B blood group secrete B and H antigens in the fluids. A secretor gene helps a person to gain a degree of protection against different environmental conditions especially the micro flora of a particular environment and also the lectins present in them. It helps them in promoting the growth of friendly, stable blood type intestinal bacterial ecosystem which depends on the blood type antigens present in the mucus of an individual. Secretor status does alter the carbohydrates present in the body fluids and their secretions and hence it also affects and influences the attachment and persistence of the micro flora present in the body. Secretors are at a higher advantage than non-secretors. Non-secretors have a potential health disadvantage. They possess many metabolic traits such as carbohydrate intolerance, immune susceptibilities. Different tests are available for determining an individuals secretor status. Most common test uses saliva or other body fluids of an individual for testing the secretor status. These tests are based on the princi ple of Agglutination Inhibition where the antigens are neutralized by the corresponding antibodies so that these antibodies will not be further be available to neutralize or agglutinate the same antigens residing on the red blood cells. ELISA could also be used for determining the presence of the secreted Lewis antigens in the saliva or other body fluids. Statistics Series, Place Reference Number Tested % Secretor % Non-secretor Frequency Frequency Negroes,New York (5) 178 61.2 38.8 0.38 0.62 Danes,Copenhagen (6) 263 74.0 26.0 0.49 0.51 Japanese,Japan . 424 75.7 24.3 0.51 0.49 Germans,Berlin (7) 363 78.0 22.0 0.53 0.47 Poles,Poland (8) 88 79.4 21.6 0.54 0.46 Whites, New York (9) 74 82.4 17.6 0.58 0.42 Finns, Helsinki (10) 196 86.3 13.7 0.63 0.37 American, Indians,New Mexico (11) 69 98.5 1.5 0.88 0.12 American, Indians, Utah (12) 79 100.0 0 1.00 0 The alleles Se and se differ in the frequency and have an anthropological value. They occur in different frequency in different populations. They have a high frequency in the American Indiana and a low frequency in the southern Indians. In US 20% of the population is secretors whereas 80% of the population consist of non-secretors. The fusion allele of the FUT2 (secretor type alpha(1,2)-fucosyltransferase) gene at a high frequency and a new se385 allele in a Korean population SECRETOR AND NON-SECRETOR A person secreting blood group antigens into the body fluids and other secretions like saliva, semen, tear, mucous in the digestive tract and respiratory cavities are named as secretors. In similar terms they put their blood type antigens in the body fluids. They secrete antigens according to their blood type, A secrete antigen A and H, B secret antigen B and H, O secrete antigen O and AB secrete A, B and H antigen. Secretors expresses Lewis b (Leb) antigens on the RBC where as non-secretor expresses Lewis a (Le a) on their RBC.These antigens in the body fluids give additional protection to the individual against the various microorganisms and the lectins present all around us. 15- 20% of the population consists of non-secretor. These individual fail to secrete the blood group antigens in their body fluids hence they become susceptible to bacterial and superficial yeast infections. A large no of them sometimes also suffer from the autoimmune disorder. This could also be correlated with the secretor and non-secretor phenotype. The body secretions of secretors and non-secretors differ quantitatively and also qualitatively. The type and quantity of the antigens present in it differ among different individuals. In some cases the non-secretors may contain the A and B antigens in the saliva but the quantity is less and even quality is very low hence they have similar functional problem. There are certain properties which are specific for secretors and differ in non-secretors. Some are listed below: Intestinal alkaline phosphatase activity ABH secretor correlates the activity of alkaline phosphatase and serum alkaline phosphatase present in the intestine. Non-secretors have low activity of alkaline phosphatase and serum alkaline phosphatase which is responsible for the breakdown of fat and assimilate calcium. Low molecular weight alkaline is present in both secretors and non-secretors and high molecular weight alkaline phosphatase is present only is secretors. Bacterial flora The ABH blood types influence the population of bacteria residing in the local vicinity of the gut mucin glycoproteins. Bacteria produce enzymes that have the capability to degrade the terminal sugar of ABH blood type antigens and which are consumed as food by them. The B antigen degrading bacteria produce enzyme to detach the terminal alpha-D-galactose and A antigen degrading bacteria produce enzyme to detach N-acetylgalactosamine which are used as a source of food by them. Blood clotting The secretor and the ABO genetics influence each other and influence the variance of the plasma concentration of vWf upto 60%. Raised levels of factor VIII and vWf may cause thrombotic and heart disease in future. Secretors have the slowest clotting time, thinnest blood, least tendency of platelet aggregation, low amount of factor VIII and von Willebrand factor (vWf). The non-secretors have highest clotting time, thick blood, high amount of factor VIII and von Willebrand factor (vWf) and low bleeding time. The blood viscosity is also influenced by the secretor phenotype. Lewis Phenotype Clotting Characteristics Le (a- b-)  Ã‚  highest activity of factor VIII and vWf Shortest bleeding times (especially in A, B and AB) Le (a+ b-) intermediate activity Shorter bleeding times (especially for O) Le (a- b+) lowest activity of factor VIII and vWf Longest bleeding times (especially for O) Lewis Blood Type and Clotting Factors Immunoglobulin levels ABH non-secretors have low levels of IgG immunoglobulin. The secretion of different concentration of different components of the blood group substances is controlled by the secretor gene and it also affects the phagocytic activity of the leucocytes which provides an added advantage to the non-secretors. The leucocytes of the non-secretors possess a greater ingestion power when compared to the secretors. The O and B blood group non-secretors have the highest phagocytic activity. The presence of level of anti-I in the serum of an individual is affected by the ABO group, secretor status and sex of the individual. The secretors females have a high level of anti-I in the serum as compared to the males. The non-secretor have low levels of IgA and IgG antibodies and hence have frequent problems with the heart valve. Genetics and Biochemical pathways The secretion of the blood group antigens in the body fluids and other secretions are genetically influenced by certain allelomorphic genes. Secretor gene contains two alleles Se and se. Se is dominant and hence is present in the homozygous or heterozygous condition in the secretors which lead to the secretion of antigens into the body fluids. se is recessive allele and is present in non-secretors in the homozygous condition. SeSe and seSe produces a dominant secretor phenotype and sese produces a recessive non-secretor phenotype. Basically three genes are responsible for the formation of the A and B antigens. They are namely ABO, Hh, and Sese genes encoding glycosyltransferases which produces the A and B antigens. H antigen present in the individual with O blood group is the precursor for the formation of A and B antigens. H antigen act as a backbone on which the A and B antigens are built up. The O gene is considered as amorphic. The allele Hh and Sese reside on each locus and are closely linked together. It is also suggested that one of the allele has arisen by the gene duplication of the other. The H allele is responsible for the production of H antigen on which antigen A and B are built. The second allele on the same locus is really rare. The product related to this allele hasnt been discovered yet and hence it is considered as amorph. The oligosaccharide responsible for the formation of the A and B antigen can exist in a simple linear fashion or a complex branched fashion. Infants A, B and H antigens contain high amount of linear chained oligosaccharide whereas oligosaccharides present in an adult contain high amount of branched chained oligosaccharides The A and B antigen is synthesized from a common intermediate known as substance H. The conversion is carried out by the addition of a sugar molecule to the non reducing end of the H oligosaccharide chains. This addition affects the reactivity of H antigen. The ABH substances are secreted in the Urinary respiratory tract, gastrointestinal tract by mucous glands residing there. The secretor gene regulates the synthesis of blood group antigens in the superficial glands of gastric and small intestinal mucosa. The secretors and non-secretors produce A and B substances which are basically glycoproteins in pylorus and Brunners glands and produce A and B substances those are soluble in alcohol and glycosphingolipids in nature. The secretors also produce ABH substances in the prostate and lactating mammary glands. The secretion of breast is rich in H substance but poor in substance A and virtually absent in substance B. The synthesis of these substances in the exocrine acini of pancreas and secretory cells of sweat gland is not controlled by the secretor gene. The blood groups substances were also detected in the collecting tubules and calyxes of the secretors but it could not be concluded that whether they are produced by the kidneys or are generally excreted. These secretions were noticed in the eight to nine weeks old salivary glands and stomach and later it appears throughout the gastrointestinal tract. Glycosphingolipids carrying the A or B oligosaccharides are present on the membranes of RBCs, epithelial and endothelial cells and are also present in the plasma in the soluble form. The glycoproteins carrying the similar A and B oligosaccharides are responsible for their activity in the body fluids. In the body fluids they are present in the secreted form. The A and B oligosaccharides which do not contain the carrier proteins are present in the milk and urine. The chromosome 19 containsFUT 1 and FUT 2 genes which code for fucosyltransferase. FUT genes numbered from 1-7 and form clusters which are responsible for the production of enzymes called as fucosyltranferases. The cluster is located on chromosome 19q13.3. Fucosyltranferase helps in the formation of fucose moiety which is added to the H antigen and further gylcosylate the A or/and B antigens. H antigen is a basic blood group antigen present in each and every human being but the content varies in different individuals of the same ABO group. A general pattern indicates that its strength varies as O>A2>A2B>B>A1>A1B. Water soluble H antigen has been demonstrated in the saliva and the body fluids of the individuals.H antigens are fucose containing glycan units which are present on the glycolipids or glycoproteins residing on the erythrocytes membrane or in the secretions. The fucosylatedglycans are the substrate for the enzyme glycosytransferases that are responsible for the formation of the epitopes for A, B and Lewis blood group antigens. Secretors contain both the alleles whereas non secretor contains the null allele for FUT2 gene. The FUT 2 gene codes for fucosyltranferaseenzyme in the exocrine tissues which lead to formation of antigens in the body secretions and body fluids. The A and B genes produce glycosyltranferase that add sugar to oligosaccharide chains that is converted to H antigen. The H antigen are constructed on the oligosaccharide chain. The oligosaccharide chains could be of two type : Type 1 and type 2. 1 carbon of the terminal 6-carbon sugar b-D-galactose (Gal) is linked to the number 3 carbon of subterminal  N-acetyl-glucosamine  (GlcNAc) in Type 1 chains and to the number 4 carbon of GlcNAc in Type 2 chains. The glycosphingolipids present in the plasma and on the membranes of glandular and parenchymal cells and glycoproteins present on the cell surfaces or body fluids carry either the type 1 or type 2 chains. The glycolipids antigens present on the RBC contain type 2 chains. A gene-specifies N-acetyl-galactosaminyl-transferase and the B gene-specifies galactosaminyl-transferase and add   GalNAc   and  Gal   respectively in alpha (1-3) linkages to the same Gal which is acted on by the H gene transferase. The H gene produces fucosyltransferase that add fucose to the terminal Galactose molecule of type 2 chain. It forms an alpha (1-2) linkage. A and B antigens are constructed when the A and B transferases attach respective sugars to the type 1 or type 2 chain substituted with Fucose. The A alleles encode UDP-GalNAc: Fuc alpha1->2 Gal alpha1->3 N-acetyl-D-galactosaminyltransferase (alpha 1->3 GalNActransferase or histo-blood group A transferase). The B alleles encode UDP-Gal: Fuc alpha1->2 Gal alpha 1->3 galactosyltransferase (alpha 1->3 galactosyltransferase or histo-blood group B transferase). O alleles encode proteins without glycosyltransferase function The secretor gene FUT2 located at 19q13.3 and codes for the activity of the glycosyltransferasesin concert with the FUT1 gene coding for H antigen, needed to assemble both the ABO and Lewis blood groups.They are active in places like goblet and mucous gland cells which interact with each other and lead to secretions of antigens in the fluids. The expression patterns of both the genes are different. The FUT1 (H) gene is dominantly expressed in the erythroid tissues which lead to the formation of the H enzyme whereas the FUT2 (secretor) gene is expressed in the secretory tissues and lead to the formation of secretor enzyme. The product of the H enzyme or H gene resides on the erythrocytes and product of secretor gene resides on mucins in secretions. If an individual lack these alleles, he/she will not be able express the above active enzymes therefore they would lack the substrates for the A or B glycosyltransferases and hence they would not express the A and B epitopes. Relationship of ABH Secretor status and Lewis system Lewis typing is sometimes used for the de facto determination of the ABH secretor status. The production of Lewis antigens is genetically controlled. Individuals possessing the Lewis (Le) gene would produce the Lewis antigens which are carried in the plasma by different substances and are absorbed onto the Red blood Cells present in ones blood. The ABO determinants and H/h blood groups determinants are structurally related to Lewis blood determinants. FUT1 provide the glycans for glycosyltransferases which convert Lewis antigen to ABH antigens. FUT2 allele is expressed in the secretor and is responsible for the expression of type1 H determinant. The secretors convert their Lewis a antigen to Lewis b therefore they are (a-b+) and the non-secretor are (a+b-) as they lack the FUT2 responsible for glycosyltransferase which could convert Lewis a antigen to Lewis b antigen. Lewis (Le) gene and Secreting (Se) gene interact with each other. Initially Lewisais formed and if Se gene is absent in an individual the Lewisa substance is absorbed on the RBC and the individual is typed as Lewisa but in secretors the Se gene controls the activation of the H gene which causes addition of an additional sugar to Lewisa which convert it to Lewisb. Secretors contain both Lewisa and Lewisb in their plasma but absorb Lewisb preferentially on the red blood cells and the individual is typed as Lewisb. Hence we could interpret that presence of Lewis gene would type an individual as Lewisa positive or Lewisb negative or vice versa. An individual could not be positive for both. A person containing both Lewis gene and Secreting gene are typed as Lewisa negative and Lewisb positive whereas a person having the Lewis gene but not the secretor gene is typed as Lewisa positive and Lewisb negative. Individual who does not have Lewis gene regardless of secretor gene is typed as Lewisa negative and Lewisb negative. Note: Lewis Double Negative (LDN) is a sub type of non secretors but Lewis typing cannot be used for them to determine the ABH secretor status. Detection methods The presence and absence of the antigens in the body fluids could be detected by Agglutination Inhibition and Lewis typing. Agglutination Inhibition test could be divided into two parts:- Part I Antibody Neutralization: To determining ones secretor status, the saliva of the individual is mixed by the antiserum (Anti-A, Anti-B or Anti-H) available commercially. In secretors the soluble substances i.e. blood group antigens will react with the antibodies present in the antiserum and will get neutralized. Part II Agglutination Inhibition: The bed blood cells obtained commercially are added to the test mixture. In secretors agglutination of the RBC do not take place as no free antibodies are available to agglutinate them. All the antibodies have reacted with the soluble antigens present in the saliva whereas in non-secretors agglutination would occur upon addition of the RBC as no blood group antigens are present in the saliva so antibodies present in the antiserum are not neutralized and hence would be free to react with the test RBC cells which are added to the test mixture. Hence agglutination is a negative test for secretor status and positive test for the non-secretor status. Note: Anti-H lectin containing phytohaemagglutinin virtually specific for human RBC. Thirteen Cucurbitaceaespecies have been investigated for the anti-H activity present in their seed lectins. Lectins has been extracted and purified from Ulexeuropaeus seeds. It could be used to demonstrate the H secretor status of blood group O individual and also for subgrouping the blood group A individuals. Lewis typing: Individuals carrying the Lewis gene produce Lewis antigens that are carried by the plasma and are also adsorbed on the red blood cells. Lewis antigens do not reside only on the red blood cells. Initially the gene gives rise to Lewisa. If Se gene is present it activates H gene which interact with the Lewisa and add a sugar to Lewisa and hence get converted it to Lewisb. Both Lewisa and Lewisb in present in the plasma of the secretors. If the Se gene is not present then the Lewisa substance is adsorbed on the red cells and individuals are typed as Lewisa. The secretor status of an individual could be determined with help of Lewisa and Lewisb antibodies mixed with an individuals saliva and observing the agglutination macroscopically. Disease Susceptibility among Secretors and Non-secretors Digestive system Non-secretors are more prone to the diseases caused by the oral bacteria in the digestive system of an individual. It includes ulcers, celiac diseases gastric carcinoma pernicious anemia etc. It could lead to dysplasia or increase in the number of cavities present in the digestive tract. Non-secretors are less resistant to the infection caused by Helicobacter pylori which could lead to the formation of peptic and duodenal ulcers. It could easily colonize and cause inflammation in the non-secretors. The non-secretors lack the blood group antigens in the mucus secretions therefore H.pylori attach to the walls of the digestive tract and cause infection. The secretors have a tendency to secrete free ABH antigens in their intestinal secretions which effect the bacterial and lectins adherence to the microvilli present in the gut. The secretors produce these antigens and act as a competitive disadvantage from preventing H.pylori attachment. These antigens act as a decoy in the secretors whi ch prevent them from attaching with the host tissues. The non-secretors also show a lower IgG immune response to the H.pylori. They have excessive rate of bleeding, perforation and development of stomach ulcers but correlation between these complications and the secretor status have not been documented yet. The non-secretors are not able to turn off the digestive enzymes and hence they produce large amount of enzyme pepsin and hence are more prone to duodenal ulcers. 50% of the duodenal ulcers are present in non-secretors. 30-40% of group O individuals are affected by the duodenal ulcers and 15- 20 % are affected by the gastric ulcers. They act as a multiplicative risk factor with the gene coding for hyperpepsinogenemia I which impact in the risk of duodenal ulcers. Group A individuals have a higher tendency of having gastric cancer and pernicious anemia. Statistics shows that 20% of the group A individuals are affected by gastric cancers and 25% are affected by the pernicious anemi a. Oral pathology The non-secretors are more prone to oral diseases like mouth and esophagus cancer, epithelial dysplasia etc. They have more cavities than secretors. Diabetes The ABH non-secretors and Lewis negative (Le a-b-) individuals have a high risk of developing insulin dependent diabetes or complications arising from diabetes. Secretors with juvenile diabetes have a low chance of developing retinopathy. The ABH non secretors which are affected by insulin dependent diabetes mellitus the mean level of C3c and C4 is lower as compared to ABH secretors. Metabolic Syndrome X The Lewis negative men are predisposing to syndrome X and prothrombic metabolism. They have high levels of BMI, SBP, triglycerides and low rather fasting levels of serum insulin and plasma glucose. This relationship is not true for women and is only applicable for the men. Respiratory System   Secretors have an added protection against the harmful environmental assaults directed towards our lungs and as usual non-secretors have a health disadvantage. They are over represented among the people suffering from influenza viruses A and B, rhinoviruses, respiratory synsytial virus and echinoviruses. The secretors who are miners or smokers do receive a protection against the disastrous effects of the cigarette smoking. Asthma is very common among the individuals working in the coal mines. Upon research it was concluded that asthma among them is also related to the non-secretor phenotype present in them. The non-secretor has a tendency to snore and are more prone to COPD (Chronic Obstructive Pulmonary Disease). Heart disease The ABH non-secretor phenotype have a high risk of developing myocardial infarction and Lewis negative individuals have a high risk of developing chronic heart disease (CHD) and also ischemic heart disease (IHD). They contain high levels of triglycerides. Alcoholism has a positive interaction with the Lewis negative individuals. Alcohol consumption is protective in these individuals. Autoimmune Disease   Autoimmune disorders such as ankylosing spondylitis, reactive arthritis, psoriatic arthropathy, Sjogrens syndrome, multiple sclerosis, and Graves disease are more prone in non-secretors. The ABH non-secretors affected with graves disease produces high levels of antitubulin antibodies as compared to secretors and are unable to produce the water soluble glycoproteins in the saliva. Fetal Loss and Infertility ABO antigens are also found on the sperm of the secretors. These are obtained from the seminal secretions present in them. ABO incompatibility could exist between the wife and husband if could affect the fertility of an individual. This issue has not been properly studied and is therefore under research. Rheumatic Fever The secretors and group O individuals are resistant to Rheumatic fever and more number of cases have been recorded in the non-secretors. Secretor status could also determine whether the rheumatic fever would be followed by streptococcal pharyngitis or not. Neisseria species The non-secretors who do not produce water soluble antigens in the saliva are at the risk of getting infected by Neisseria meningcococcal disease. The immune capabilities of the secretor provide a relative protection in the secretors. The ABH non-secretors produce low level of anti-meningococcal salivary IgM antibodies which provide protection to the secretors against the microorganism. Candida species Non-secretors are barriers of candida species and therefore are frequently affected by the candida infections. The glycocompounds secreted by secretors in the body fluids inhibit adhesins present on the yeast which are responsible for their adhesion with the body tissues. This leads to the development of the chronic hyperplastic Candidiasis. Statistics shows that 68% on the non-secretors are affected by chronic hyperplastic candidiasis. Non-secretor women are affected by recurrent idiopathic vulvovaginal Candidiasis. An individual with a combination of non-secretors and absence of Lewis gene are at relative risk of developing recurrent idiopathic vulvovaginal Candidiasis. Tumor Markers The individuals with inactive Se (se/se) alleles and homozygous active Le alleles (Le/Le) allele have a highest mean value of CA19-9 tumor marker. The Lewis negative individuals irrespective of Se genotype have negative values for CA19-9. The Lewis negative individuals have higher mean value for DU PAN-2 as compared to Le-positive individuals. We can conclude that CA 19-9 marker is not an appropriate tumor marker for Le-negative individuals but DU-PAN-9 is an appropriate tumor marker. Bacteria Urinary Tract Infections Non-secretors are at a higher risk of getting recurrent urinary tract infection (UTI) and renal scars as compared to secretors. This susceptibility is higher among negative Lewis subset. Statistics of a study done on women affected with recurrent urinary tract infection stated that 29% of the non-secretor women were affected by UTI and 26% of Lewis (a-b-) women were affected by the UTI. The non-secretor phenotype and blood group B and AB phenotype work together to increase the risk of UTI among women. Women and children suffering from renal scarring with and without the antibiotic treatment for UTI are prone to UTI and pyelonephritis. 55-60% of non-secretors develop renal scars and 16% on secretors develop renal scars. C-reactive protein levels, erythrocyte sedimentation rate and body temperature are higher in the non-secretors that in secretors with recurrent UTI. Conclusion It concludes that there exist a statistical association between the individuals blood-group secretor phenotype and the diseases they are susceptible to. So knowing your secretor status is advantageous as we can use the nutritional supplements more intelligently and effectively. It also makes us aware of the diseases, illness and metabolic dysfunction we are prone to, difference in the levels of intestinal alkaline phosphatase activity, propensities towards blood clotting, tumor markers and different ingredients of breast milk so that we can manage them before hand and would be prepared for them in the near future.

Monday, August 19, 2019

Essay --

All around the book of Deuteronomy, God gave quick directions to His people on how they were to live when they arrived in Canaan, the region that God had ensured to Abraham. These guidelines even consolidated the kind of government they should just structure. At the start, they could be supervised by a game plan of judges. By then, in Deuteronomy 17:14-15, God told the Israelites that rulers should just run over the people, however simply those masters who were especially picked by God. The Hebrews ended up in the same position as the first generation that left Israel. As the Israelites, all had consented to be in pledge with the Lord. Furthermore additionally like the Israelites, not each one of the said who submitted to the pledge truly accepted. God cautioned the Israelites to endure in their confidence yet the majority of the original did not. Just Caleb and Joshua from the original were permitted into the Promised Land. Similarly, it was conceivable that just a couple of the Heb rews being tended to in this letter might endure and enter into the guarantees of Christ. (The Nation of Israel) The most significant thing to recognize in 3:18–19 is the nearby association between insubordination and unbelief. In verse 18 we are told that God banned the insubordinate from the Promised Land. Verse 19 lets us know that the original did not enter the Promised Land in light of rebellion. This lets us know that noncompliance and unbelief are eventually synonymous. In the event that an individual proclaims to have faith in the Lord yet carries on with a life of ceaseless defiance to Him, that individual is in jeopardy of being considered as a real part of the heretic. That unbelief and rebellion are eventually synonymous and should not am... ...in and again, God sent prophets to the people to alert them that there could be grave comes about for their insubordination. The last fragment of the Old Testament records the articulations that God charged His prophets to say. Every desire God made through His prophets for the destruction and untouchable of Israel happened. (The Nation of Israel) To see the solicitation of the works of the prophets, we can put them into a chart equivalent to the one we made for the Israeli rulers. The events that were happening all around the times of I and Ii Samuel, I and Ii Kings and I and Ii Chronicles were the precise ones that the prophets tried to alert the people of Israel about. Israel's history substantiates the truthfulness of God's expressions. The individuals did not remain unwavering to God and they were determined from the area and the sanctuary was left in remains.

Sunday, August 18, 2019

My Philosophy of Education :: Essays Papers

My Philosophy of Education I believe that education should be looked as as a desire to acquire all possible knowledge, not as a requirement or something that can be formally examined by standardized tests. There are numerous ways that children learn and I want to be able to encourage as much learning as possible for each child. I believe that using many methods of instruction is the most effective way of teaching to these various ways of learning. These methods include group work, hands-on activities, buddy work, etc. Assessment of children should follow the same idea. When children get the chance to perform on different assessments, they can adequately show their strengths and weaknesses. I do not wish to rely on tests only to assess the students in my class. Some types of assessment that I think should be inlcuded in a classroom are journals, presentations, projects and interviews. I also think that the classroom should be run with the help of the children. By distributing jobs among the childre n and everyone participating in the classroom, the students will form a sense of togetherness. This will eventually create a community within the classroom. I feel that this community of learners is essential for the students to perform effectively and efficiently. They will feel comfortable in the environment and will not be afraid to take risks or ask questions. The teacher will also be a member of this community and will not be seen as unapproachable or as the only leader. The teacher should also not be seen as the facilitator of all information in the classroom. The students should be looking to other sources for information, including each other, books, and technology. There should be many points of view exemplified in each subject area. The students will be able to state their opinion and also listen to the other students' views. I believe that the curriculum should be flexible. While teaching a certain subject, if the students wish to learn about something else or move into a different idea, I want to be able to do that. I do not want to say that we aren't going to have enough time to cover something.

Death Penalty Essay -- essays research papers

Death Penalty: Barbaric or Justice?   Ã‚  Ã‚  Ã‚  Ã‚  Julian Ptachin was only 14 years old in October 1997 when a drunk driver smashed into his parents van. His Dad, a physician, had to hold Julian while he died on the side of the road. The drunk driver was a three-timed convicted, repeat offender. He was convicted of second-degree murder and was ordered to serve eight years in jail. Doesn’t something seem wrong with this picture? Repeat crime convicts are running down the streets rapid: endangering our children, our loved ones, and even us.   Ã‚  Ã‚  Ã‚  Ã‚     Ã‚  Ã‚  Ã‚  Ã‚  What can us, as citizens, do to stop these heinous crimes? The Death Penalty. The Death Penalty has been around for several hundred years. One of the first people to first use the death penalty was the Babylonians who would use the system of â€Å"an eye for an eye, and a tooth for a tooth.†(Matthew 5:38, KJV) Throughout this reign the Babylonians were very successful and were considered very strong when it came to war tactics. In ancient times there was no repeat offenders, no repeated crimes, and everybody knew what they had to do to stay alive.   Ã‚  Ã‚  Ã‚  Ã‚  Today repeat offenders are walking our streets that we walk on everyday. Many newspapers put out names of sexual offenders who are let out on bail, but yet receive lots of negative feedback for the use of privacy. The American people should have a right to know who the sex offenders are and where i...

Saturday, August 17, 2019

John Locke’s Influence on United States Government

John Locke and American Government John Locke is one of the most influential writers and political philosophers in history. On top of that he is most likely the most influential in the forming of the American constitution. Many of the ideas that Locke had formed were used in the creation of the United States Constitution. He left an abundance of thoughts and ideas on human understanding, religion, economics, and politics that still influence the structure, environment, and operation of public administration today. One of Locke’s most noted ideas is his concept of the separation of powers. This concept was the most influential on the structure of American government. The idea behind it was to make sure that no branch of government would attain too much power. This was done through a system of checks and balances in which each branch of government had the power to override another branch in case they did something wrong. The affect this had on American government created the structure that we see today between the Judicial, Legislative, and executive branches. Another one is very well known ideas was the idea of natural rights. The natural rights were rights that every citizen had obtained upon being born. These rights included life, liberty, property, and the pursuit of happiness. Locke had said that these rights should never be able to be taken away by the government. He believed that it was the government’s job to protect these rights of the citizens instead of take them away. Locke had also believed in the consent of the governed. He believed that a group of people could not be governed unless they given consent to the government. Through this he questioned whether monarchy is legitimate if it is not chosen by the people. This led to the idea known as the social contract, in which the government protected the people’s natural rights in exchange for the people’s consent to be governed. John Locke himself had said, â€Å"every man being, as has been should, naturally free, and nothing being able to put himself into subjection to any earthly power, but only his own consent†. John Locke greatly influenced the structure of American government that we have today. Without John Locke and his ideas our government would be completely different and it is possible that the American Revolution would have never happened.

Friday, August 16, 2019

Complaint and Present Canteen Management

To  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   :   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Mr. Hasnan bin Jalal, The Principal,   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Sekolah Menengah Kebangsaan Permata From  Ã‚   :            Ã‚   Malik bin Abdul Date  Ã‚  Ã‚   :  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   24 March 2011 Report about the School Canteen I am writing this report is to draw your attention regarding the school canteen. Many of the students of Sekolah Menengah Kebangsaan Permata are unhappy about the conditions at the school canteen. There were lots of complaints regarding this issue. In the first place, there are insufficient tables and benches.Our school has a student population of over 1 000. There is only one period of recess time for all forms. More than 80 per cent of the students go to the canteen during recess to buy food and drinks. Unfortunately, there are only about twenty-five tables and fifty benches which can accommodate less than half the number of students. As a result, many students have to stand while eating. The food sold at the canteen not only expensive but lacks of variety. The menu is the same every day.For the past five years, ever since the present canteen management took over, students go back to the same food. The hygiene and preparation of food leave a lot to be desired. The food and drinks are not covered. They way canteen attendants dress speak volume about hygiene. With their lackadaisical attitude, the food they sell would one way or the other become contaminated. My fourth complaint about the canteen pertains to the etiquette of the canteen workers. They are rude and arrogant. They often shout at students.The students are always on the receiving end of their bad moods. We hope that conditions at the canteen will improve. The canteen should provide better amenities. There should also be a different menu everyday so that students will not have to taste the same food day in and day out. Cleanliness should be given top priority. We hope that you will look into our complaints and take steps to remedy the situation. The students are prepared to boycott the canteen if their complaints go unheeded. Reported by: Malik Malik bin. Mohd Jalil 314 words

Thursday, August 15, 2019

Cultural Difference Essay

Compare and Contrast the Poetry of James Berry and John Betjeman, with particular reference to the Cultural Differences. Refer to at Least two Poems by each Poet  James Berry’s poems are written from the perspective of a lady named Lucy. Lucy moved to England because she had heard the streets were practically paved with gold there. She writes letters to her friend Leela in the form of poems. Lucy regrets her move to England in a lot of ways and finds it gloomy and cold. She misses Jamaica and doesn’t really like London but she is too proud to admit that, so her letters also contain a number of positive yet vain sounding points about the advantages of living in England, such as, â€Å"An’ doctors free.† Lucy writes of how she has, â€Å"turned a battery hen,† in the poem ‘Lucy’s Letters’ because she feels trapped in London. She was used to a relaxed and friendly way of life in Jamaica so the culture in London came as a big shock to her. London is a lot bigger and much less friendly than Jamaica. In Jamaica everyone knows each other so Leela asked Lucy in a letter to her if she’d ever met the Queen. Lucy is used to the unspoilt beauty of the Jamaican scenery so London comes as a big change. She describes it to Leela as: â€Å"A parish  Of a pasture-lan what  Grown crisscross streets.†Ã‚  In Jamaica Lucy could leave her door unlocked but write of how she can’t do that in London:  Ã¢â‚¬Å"I carry keys everywhere  Life here’s no opensummer.†Ã‚  She sees the lifestyle as monotonous because every day seems the same. She feels in some ways that she doesn’t really belong in London. In the poem ‘From Lucy: Englan’ Lady’ she describes the Queen as being, â€Å"Like she a space touris’,† because she is somewhat alienated from the rest of the population. Lucy feels she can relate to her because she feels alienated too. Lucy ends the poem with the Jamaican proverb, â€Å"Bird sing sweet for its nest,† meaning you should stick to what you’re suited to. When Lucy travels back to Jamaica, she realises it has changed and nothing is as she remembered it. She is glad to come back but feels she doesn’t really belong there either anymore. Some things like the sun, the sea and the fruit they eat hasn’t changed:  Ã¢â‚¬Å"I eat a mango under tree  A soursop ripened for me  A pawpaw kept.†Ã‚  She appreciates the sun more after being in London for so long as well and she is pleased these things are as she remembered them. The landscape has changed but more importantly, the people have too. Everyone she knew has changed and she is no longer friend with everyone. She writes about her holiday in the poem ‘From Lucy: Holiday Reflections’: â€Å"I see  Puppa is bones in the groun’,  Mumma can’t see to climb mount’n  Lan’.†Ã‚  She knew her father was dead but it doesn’t really hit home until she sees it for herself because in her mind he was still alive. She uses personification when describing the landscape, writing, â€Å"Big fig tree gone as ghost.† The one thing that hasn’t really changed is Leela who is just as she remembered her. She is glad they are still friends though, even though Lucy has changed, finishing the poem by writing: â€Å"Too many sea waves passed between  Us, chile. Let us remind the other,  Ã¢â‚¬ËœLength of time gets length of rope buried’.†Ã‚  Betjeman’s poems are named after counties and describe the country lifestyle he was used to when he was younger. His county poems are written in two contrasting sections. In the poem ‘Hertfordshire’ Betjeman writes of how he was made to join his father’s shooting syndicate. His father thought he was a milksop after he accidentally fired a gun into the ground, saying: â€Å"How many times must I explain?  The way a boy should hold a gun?†Ã‚  In the second half of the poem, Betjeman writes of how that large, open countryside has been replaced with rows of identical and box-like houses. He writes of how the old flint churches and thatched cottages look, â€Å"strange and ill.† He sums this up by writing, â€Å"One can’t be sure where London ends,† this relates to an earlier line in the poem, naming villages that used to be miles away from London which are now part of it. It caused his father great pain to see his son couldn’t shoot, which contrasts greatly with the happy relationship between Leela and Lucy in Berry’s poetry. Betjeman ends the poem with the words: â€Å"Far more would these have caused him pain  Than my mishandling of a gun.†Ã‚  This mean even though he was upset that his son couldn’t shoot, it would have broken his heart to see the Hertfordshire countryside had been urbanised. It is also ironic that the ones who appreciated it were also the ones who destroyed it for the next generation.  In the poem ‘Essex’, Betjeman writes as he looks at a colour plate book. The book contains pictures of Edwardian England. Betjeman describes it as being:  Ã¢â‚¬Å"Like Streams the little by-roads run  Through oats and barley round a hill  To where blue willows catch the sun  By some white weathered boarded mill.†

Wednesday, August 14, 2019

Companies Are Incorporated And Operated On The Premises Of Agency Theory Accounting Essay

Companies are incorporated and operated on the premises of Agency Theory. The Agency Theory spells out that there should be a working relationship between the direction of the company and the investors of the company in order to maximise the stockholders wealth. The way for the traditional research of corporate administration was set up by Berle and Means ( 1932 ) , when they presented an bureau theory to divide ownership from control. This theory to divide ownership from control led to the development of the bureau theory. The early rivals of the bureau theory assert that the bureau relationship is a contract under which one party ( the principal ) engages another party ( the agent ) to execute some service on their behalf. ( Coase, 1937, Jenson and Meckling, 1976 and Fama and Jensan, 1983 ) . The bureau theory is of import, yet different writers and research workers see it from controversial positions. The footing of the bureau theory appears from the separation of direction and fundss Sleifer & A ; Vish, ( 1996 ) . Agency theory is widely used as a model in many research of corporate administration. It is used in research state of affairss where the benefit on one party ( the principal ) is dependent on the behavior and actions of 2nd party ( the agent ) . The constructs and rules of corporate administration are chiefly based upon the bureau theory. Good corporate administration requires an effectual board to take the company so that it creates wealth for the stockholders and besides to run into other stakeholders ‘ outlooks. For illustration, Barclays Board of Directors, guided by Group Chairman Marcus Agius, runs the concern on behalf of stockholders. As a scheduled company on the London Stock Exchange, Barclays meets the footings with the UK Combined Code on Corporate Governance. Barclays Executive Committee includes the most superior leaders in the concern, headed up by Group Chief Executive John Varley. It has proclaimed the enlargement of its Executive Committee and alters to its organisation and senior direction undertakings, puting its concerns to convey strongly in the developing fiscal services industry. Stockholders are placed as one of the stakeholders that directors must see throughout their determination doing on how a corporation can and should be set and implement way Jonker J, ( 2003 ) in Freeman ( 1984 ) . Although the bureau theory is expected to make a smooth and good relationship between the principal and the agent, there are some jobs which arise because of the impossibleness of absolutely undertaking for every action of an agent whose determination affects both his ain public assistance and the public assistance of the principal, ( Brennan, 1995 ) . Agency theory is concentrating at everyplace bureau connexion, in which one party ( the principal ) designate work to another ( the agent ) , who carry out that work. The theory is related with work outing two jobs that can happen in bureau relationships. The first is the bureau trouble that happens when ( a ) the yearning or aim of the principal and agent clang and ( B ) it is difficult or dearly-won for the principal to corroborate that the agent had acted appropriately. The 2nd is the trouble of hazard sharing that happens when the principal and agent have dissimilar attack in the way of the hazard. The job here is that the principal and the agent may prefer different actions because of the different hazard penchants ( Elsenhadt, 1989 ) . Barclays Capital and/or its associates may, from clip to clip, have topographic points in, and may, as chief or agent, purchase or retail the Securities. Barclays Capital shall non be lawfully responsible to any single on any base for any dead or costs go oning straight or indirectly out of the exercising of or dependence on any of the appraisal or in sequence set out herein. ( hypertext transfer protocol: //www.barx.com/legal/index.html ) From the bureau theory position, the aim of corporate administration is to guarantee that directors resort to value maximising schemes ( Shleifer and Vishny, 1997 ) . There have besides been efforts to linkthe â€Å" resource based position † and the â€Å" managerial rents theory † ( Castanians and Helfat, 2001 ) with corporate administration, in the strategic direction literature. This position maintains that corporate administration variables are the factors, which are considered cardinal and of import to the effectivity of Corporate Governance. Corporate Governance ‘s cardinal variables are closely associated with the success or failure of companies and a cardinal managerial resource or human capital and therefore a possible beginning of competitory advantage to the house. Many companies have failed in the United Kingdom and this has stimulated argument about Corporate Governance. The prostration of the Maxwell Publishing Group in the late eightiess stimulated the Cadbury Report in 1992. In the 1990s instances like the Poly Peck, BCCI and Marconi farther necessitated a demand for proper Corporate Governance. In looking at all these incidences of Corporate Governance inefficiencies and ineffectualness, it is noticeable that some instances are clearly a affair of concern planning and hapless decision-making by direction. The strategic planning is the exclusive duty of the board. This therefore points it out that the board composing plays a major function in the success or failure of the concern. As is clear now, BP could hold put in more honest to extra diminish or maintain off from the jeopardy of sloping oil into the ocean. Even with Green Project Management, if BP ‘s pick was non to pass more in a hazard response strategy, so possibly they should hold approximate the party costs necessary for a clean-up activity as they are at present commencing. ( hypertext transfer protocol: //sustainablecitiescollective.com/richmaltzman/ ) The prostration of many companies is as a consequence of fraud. Fraud could be in signifier of cover-up and deception by direction or in some instances it could be the combination of both. The WorldCom in the United States and Maxwell, BCCI and Poly Peck in the United Kingdom are authoritative and living illustrations. Another issue is the inquiry of regulative inadvertence, as highlighted in the instance of Enron. Then Combined Code was introduced in the UK to reconstruct the investor ‘s assurance following many prostrations and company failures of those large corporations. The Directors are accountable for internal control in HSBC and for reconsidering its efficiency. Events have been planned for saving assets against illegal usage or disposition ; for continuing good accounting records ; and for the consistence of pecuniary information used within the concern or for journal. Such events are considered to pull off instead than make off with the hazard of dislocation to achieve concern aims and can merely offer reasonable and non complete declaration aligned with important misstatement, mistake, losingss or fraud. The actions besides allow HSBC Holdings to unclutter its duties under the Handbook of Rules and Guidance issued by the Financial Services Authority, HSBC ‘s guide supervisory organic structure. ( hypertext transfer protocol: //www.hsbc.com )2.2.2 The Original Combined Code-1998The Combined Code is made up of three chief studies. The original combined codification incorporates the recommendations of the Cadbury, Greenbury and Hampel studi esCadbury Report ( Cadbury, Sir Adrian, 1992 )The Committee issued a scope of recommendations for good corporate administration in a Code of Best Practice. The Cadbury study addressed four chief countries viz. , Board of Directors, Non-executive managers, Executive managers and Company Accounts. The chief recommendations of the Cadbury study are explained below: ( ICSA 2003 pp 151 – 152 ) .Board of managersThe board should run into on a regular basis, supervising the public presentation of the executive direction. Control over the company should be exercised jointly by the board of managers as a whole, with a clearly recognized division of duty between the main executive and the president to avoid domination of the board by a individual person or by a little group of executive managers. The Code argued that it was desirable to divide these functions, so that the same individual did non transport out both. It did non province that the same individual should ne'er be both president and main executive, but recommended that when this did go on, there should be a strong independent component on board to move as a counter-force, with a recognized senior member to take them. The board should hold formal agenda of affairs specifically reserved to it for determination to guarantee way and control is steadfastly in its custodies and does non let power transportation to an almighty main executive or president.Non-executive managersThere should be a sufficient figure of non-executives, suitably qualified for the positions to transport weight. Non-executive managers should be able to convey independent judgement and experience to the deliberations of the that the executive managers on their ain would miss. Non-executive managers should be selected through a formal procedure and they should be appointed for a fixed term. Reappointment at the terminal of that term should non be automatic.Executive managersThe service contract of an executive manager should non transcend three old ages without stockholders blessing. The intent of this demand was to put a bound to the size of the pay-off for a manager who is forced to go forth the company, or illustration as a hapless public presentation and stockholder force per unit area. The wage of the executive managers should be decided by a wage commission, dwelling entirely or chiefly of non-executives.The histories of the companyThe board should set up an audit commission of at least three non-executive managers, with written footings of mention. The board of managers should show a balanced and apprehensible appraisal of the company ‘s fiscal place to the stockholders including a statement in the one-year study about the company ‘s abi lity to go on as a traveling concern. The managers should describe to the stockholders on the full system of the internal control in the company. The board of Lloyds group believe that superior administration is innermost to achieving the Group ‘s regulating thought of maximizing stockholder monetary value in surplus of clip. That has been highest in managers ‘ attending when seting on the values restricted in the combined codification on corporate administration issued by the Financial Reporting Council. ( hypertext transfer protocol: //www.guardian.co.uk/business/ ) A board incorporating executive and non-executive managers with wide cognition guide the Lloyds group.A The choice of managers is measured by the board and, supervising the necessities in the articles of association, they must stand for ballot by the stockholders at the first one-year general meeting following their choice and must go forth, and may acquire up for re-election by the stockholders, as a lower limit every three old ages. ( hypertext transfer protocol: //www.lloydsbankinggroup.com/ )Greenbury Report ( Greenbury, Sr Richard, 1995 )In 1995 a commission was set up to look into the wage bundle and service contracts of the managers. The concern was centered around the ‘fat cat issue ‘ . This referred to the managers who paid themselves immense wages. There was another concern sing the failure of wage bundles to supply a suited inducement for managers to execute better. The study recommended the followers are other things: Directors ‘ wage and service contrac ts ; Disclosure and Approval and Remuneration Committee ( ICSA 2003, pp 152 – 153 ) .Directors ‘ wage and Service contractsA wage commission dwelling wholly of non-executive managers should make up one's mind the wage of the executive managers ‘ .The maximal notice period in an executive manager ‘s service contract should usually be 12 months, compared to the three old ages maximum recommended by the Cadbury codification. In exceeding fortunes notice periods of up to two old ages might be sensible, by merely on occasion should a notice period exceed this. The Report included general recommendation about wage, but most of these were slackly phrased and unfastened to wide reading. They included nevertheless: Executive wage should non be inordinate, but the wage commission should offer wage bundles that are sufficient to pull, retain and actuate person of the needed quality. The public presentation related elements of the wage should make a nexus between the involvements of the manager with those of the stockholders. The public presentation standards should be ‘relevant, stretching and designed to heighten the concern affairs ‘ .Matters for the wage commission to see should include the phasing of any reward strategy s, the nature of any portion option bundle and the deductions of each component of the wage bundle for payments into the manager ‘s pension strategy. Puting an upper bound to options granted as portion of a manager ‘s wage strategy should non be issued at a price reduction. Before Greenbury, it was rather usual in the UK to allow portion options to managers with an exercising monetary value at some price reduction to the current market monetary value. Share options should be granted to managers in phased sums over clip the in individual big awards. A steadfast line should be taken on the payment of compensation to managers dismissed for unsatisfactory public presentation. In the public perceptual experience, a high wage off to an outgoing main executive can look really much like a wages for failure. The Board of Ladbrokes Plc manus over the Remuneration Committee with the liability for the scheme in regard of the executive managers and senior executives. In regard of other workers the executive managers have been manus over answerability to run within the wage scheme and program construction recognized by the Board. The Board at the advice of the Nomination Committee makes agenda to the committee, which discuss with the Chairman of the Remuneration Committee. The Committee normally request the Chief Executive and the HR manager to be present at commission conference about suggestion depicting to the payment of the executive managers, other than when their single payment is conversed. The Company Secretary takes stairss as secretary to the Committee. The Committee and Board think that it is in the security of stockholders to protect some of the betting and bet oning industry ‘s most superb and profitable individuals by given that to the full spirited wage. The Committee has judgement to believe corporate presentation on environmental, societal and administration ( ESG ) affairs when seting the wage of executive managers. The commission has warrant that ESG hazards are non being lifted by the motive agreement for senior direction accidentally interesting careless activities. ( http: //ar2008.ladbrokesplc.com/remuneration-report )Disclosure and blessingGreater revelation about the wage of single manager ‘s.The one-year study and histories should unwrap for each named manager the elements of wage, such as wages and fees, one-year and deferred fillips, compensation for the loss of office, portion options and any other long -term inducement strategy. An account and Justification should be provided whenever any component of the wage other than basic wage is pension able. A revelation should be made of nay manager with a notice period in surplus of 12 months in his her service, contract, together with an account of the grounds. The elaborate revelations on the manager ‘s wage should be checked any external hearers. The president of the wage commission should go to the one-year general meeting, where the stockholders should hold an chance for a inquiry sand reply session. The audit commission of Unilever includes a least of three or more non-executive managers ; two of them stand forA a quorum. The commission assists the boards in fulfilling their error undertakings in regard of the truthfulness of Unilever ‘s fiscal statements ; hazard direction and internal control activities ; conformance with legal and narrow petitions ; the public presentation, makings and independency of the outside hearers ; and the presentation of the internal audit intent. The commission is besides in a straight-line accountable, expose to local regulations refering stockholder indorsement, for the proposal, wages and failure to notice of the external hearers. The disclosure commission includes the Group Controller, the Chief Legal Officer, the Group Treasurer and the NV Corporate Legal Counsel. The rule of the commission is to help the boards make certain that fiscal and other information that have to be revealed openly by Unilever is revealed in a timely mode and that the information that is revealed is absolute and right. ( hypertext transfer protocol: //www.unilever.com/investorrelations/corp_governance/ )The wage commission studyThere should be a study in the one-year study and histories on managers ‘ wage policy demoing how wage compares with other, similar companies. All fillip strategies should depend on satisfactory public presentation standards. Long term inducement strategies should be submitted o the stockholders for the blessing, in progress of presenting them. The Greenbury study did non give guidelines of make up one's minding what constitutes ‘satisfactory public presentation ‘ , and as a consequence this component of the recommendations has been interpreted widely. For illustration, there were no guidelines about inducements for longer term public presentation. The study should include a statement on the company ‘s policy for allowing portion options and other long term inducement strategies, together with a justification for any going from that policy in the policy under the reappraisal.Hampel Report ( Hampel Committee, 1998 )The commission was set up in 1995 to reexamine the advancement of the execution of the findings of the Cadbury and Greenbury Committees. The Hampel study proposed the consolidation of the Cadbury study, Greenbury study, and Hampel study into one amalgamate codification. The Hampel study described its undertaking as ‘reviewing the substance and execution of the Cadbury codification.2.2.3 The revised combined code – 2003The original Combined Code was proposed by Hampel and latter it was revised and brought update by Higgs in 2003. The key alterations made by Higgs are in the alterations of the composing of managers. He proposed the addition of non- executive managers and the assignment of a senior independent executive manager.Contentss of the revised codificationThe function and duties of the board, the president and the NED ‘s are more clearly defined. The functions of president and main executive should be separate- the president should fulfill the standards for independency on assignment, but should non, thenceforth, be considered independent when measuring the balance of board rank. The president is give clear duties, including the debut of new managers and guaranting the proper flow of information to board members. No person should be appointed to a 2nd chairmanship of a FTSE 100 company. At least half of the board larger companies, excepting the president, should be independent NED ‘s. The standard for independency are defined. The board, it commission and managers should be capable to one-year public presentation reappraisal. At least one member of the audit commission should hold recent and relevant fiscal experience. In softening of the line adopted the Higgs Report, it is now acknowledged that: The president nominations commission, anticipate where the commission is sing the assignment of the president ‘s replacement. Smaller companies ( below the FTSE 350 ) may happen it hard to run into the commissariats associating to board and commission composing hence, such companies should hold at least two independent NED ‘s ( instead than a bulk ) and may hold smaller wage and audit companies. Where the companies wish to retain a NED for more than six old ages, their farther assignment will non will non necessitate to be explained in the one-year study but such be capable to â€Å" peculiarly strict reappraisal † . The function of the senior NED should be clarified and the importance of the president ‘s function in pass oning with stockholders and supplying leading to the NED ‘s emphasized. The purpose of the FRC has been to heighten board effectivity and better investor assurance by raising criterions of corporate administration. Companies are encouraged to do an early study on the stairss, which they are taking to implement the new Code, instead than waiting until their coverage year-end. In visible radiation of these amendments of the Code, companies will necessitate to transport out a comprehensive reappraisal of their corporate administration policies and processs and see how best to react. Over the following few months these responses will, no uncertainty, be the topic of considerable investor, regulative and media involvement.2.2.4 The revised combined code – 2005In 2004, the Financial Responsible Council established the Turnbull Review Group that saw the issue of the ‘Guidance for Directors on the Combined Code ‘ . The chief accent of the Turnbull study was to fasten internal control ( Turnbull Report, 1999 ) .Significance of Internal Controls and hazard directionThe significance of internal controls has been sketched in Turnbull study as follows: A dependable technique of internal control adds to preservation the stockholders ‘ spending and the company ‘s resources. A company ‘s strategy of internal control as a important duty in direction of hazards that is of import to the executing of its concern aims. Internal control smoothes the advancement of the success and competency of operations ; aids guarantee the dependableness of internal and external exposure and helps fulfilment with Torahs and ordinances. Efficient pecuniary monitoring, every bit good as the saving of appropriate clerking records, is a important edifice block of internal control. They aid certify that the company is non without cause uncovered to preventable fiscal hazards and that fiscal informations employed inside the concern and for diary is consistent. They besides add to the saving of belongings, together with the turning away and find of cozenage. A company ‘s aims, its internal constitution and the background in which it maps are repeatedly developing and, as a consequence, the hazard it tackles is repeatedly changing. A sound system of interior influence accordingly depends on a methodical and usual appraisal of the nature and sum of the jeopardy, which the company is uncovered. Since net incomes are, in portion, the recompense for booming risk-taking in concern, the ground of internal control is to help administer and form hazard suited instead than to acquire rid of it. The hazard direction system in J Sainsbury plc has been prepared all over the twelvemonth and up to the day of the month of countenance of the Annual Report and Financial Statements. Acknowledging that hazard is an intrinsic fraction of making concern, the strategy is intended to acknowledge major menaces and do available declaration that these hazards are wholly recognized and handled. It is besides maintained by a hazard policy and regulations on how to be relevant the scheme, which are connected all the manner through the Company. The success of the process is reconsidered two times a twelvemonth by the Audit Committee, which so reports to the Board. The Functioning Board maintain up a hazard registry, which is often re-examined by the Committee and officially, conversed with the Board. The registry holds the important hazards facing the Company and recognizes the possible influence and chance of the hazard at both a gross ( pre mitigating controls ) and a net ( station mitigating controls ) phase. Where the net hazard needs extra behaviors, these are decided with exact timelines. These workss are narrowly checked until they are wholly applied. ( http: //www.j-sainsbury.co.uk/ )Aim of the studyTo guarantee that concerns have sound internal controls embedded in the concern processes as the companies pursue their aims. To guarantee that the internal control remain relevant over clip in the continually germinating concern environment and to enable each company to use it in a mode which takes history of its peculiar fortunes. The guideline on internal controls requires the managers to exert judgement in reexamining how the company has implemented the demands of the Combined Code associating to internal control and coverage to stockholders.Internal control demands of the combined codificationThe rule C2 of the combined codification provinces that ‘ The board should keep a sound system of internal control to safeguard stockholders ‘ investing and the company ‘s assets. The proviso C2.1 states ‘That managers should, carry on a reappraisal of the effectivity of the group ‘s system of internal control and should describe to stockholders that they have done so. This reappraisal should cover all stuff controls, including fiscal, operational and conformity controls and hazard direction systems. Turnbull Report, ( 2004 ) . The Board of Marks and Spencer have on the whole duty for administering the concern expeditiously – confirms hazards are directed and it ‘s all under review. Internal controls and hazard direction are intended to boundary the possibility of dislocation to achieve corporate aims. Autonomous declaration is offered by the outside hearers and internal audit, who manus over their decision often to the Audit Committee. They have taken on an integrated method to put on the line direction, autonomous averment and internal controls to attest better connexion across re-examine and assessment of hazard. They are a broad concern with a wide assortment of aims and hazards. The Board is accountable for doing certain that all goes harmonizing to agreement and that describing lines and individual answerabilities are obviously mute. They besides have runing schemes and events covering the whole thing from fiscal planning and coverage, capital outgo, undertaking administration and informa tion security to concern stableness, worker public presentation direction and how they do concern. ( http: //annualreport.marksandspencer.com/governance/governance-report )2.2.5 The revised combined code – 2006This codification supersedes and replaces the Combined Code issued in 2003. It follows a reappraisal by the Financial Reporting Council of the execution of the Code 2005 and subsequent audience on possible amendments to the Code. The Financial Services Authority, as the UK Listing Authority, is obliged by legislative act to transport out a separate audience before listed companies can be officially required under the Listing Rules to unwrap how they have applied this new version of the Combined Code. This audience is expected to get down September 2006 and, capable to positions received, the Listing Rules would be expected to use to the new version of the Combined Code with consequence from some clip in the 2nd one-fourth of 2007. In the interim, in position of the limited nature of the alterations and strong support that they have received, the FRC would promote companies and investors to use the revised Code voluntarily for describing old ages get downing on or after 1 November 2006. The Code holds cardinal and subsequent doctrine and status. The Listing Rule needs listed companies to make a disclosure statement in two parts in relation to the Code. In the primary portion of the declaration, the company has to account on how it be relevant the chief beliefs in the Code. This should cover both chief and back uping values. The signifier and substance of this division of the statement are non set, the significance being that companies should hold a free manus to depict their authorization regulations in the visible radiation of the political orientation, every bit good as any peculiar state of affairs be relevant to so which have guided to a specific method. This â€Å" comply or explain † method has been in operation for over 10 old ages and the lissomeness it proposes has been extensively welcomed both by company boards and by stockholders. It is for investors and others to measure the company ‘s statements.The statement of conformityA company that ha s non complied with the commissariats of the combined codification in full throughout the period must stipulate the Code commissariats, with which it has non complied, for what portion of the period non-compliance continued and give grounds for non-compliance. This is a demand of the Listing Rules of the Stock Exchange. Ignoring the commissariats of the codification is non an option, but the company has good substantial grounds for diverting the commissariats, it is up to the stockholders to make up one's mind whether the ground given by the company is valid or non. If the managers an explain converting the stockholders that the going from the codification commissariats is in the best involvement of the company, the non-compliance is improbable to be an issue.Criticisms of combined codificationThe Higgs and Smith studies were widely welcomed by different boards like the Financial Reporting Council ( FRC ) on the revised combined codification, but besides identified some strong unfav orable judgments were simply on the functions and responsibilities of the president and the period of term of office for managers. The board suggested that the combined codification needed to set more attempt into doing the system work, there would be occasions when a company would take to utilize the â€Å" explain † option, and institutional investors should see such accounts carefully, giving grounds if they did non accept the account.